HORDB

ID: hor004910
Uniprot ID: P69057
Protein name: Oxytocin
Gene name: OXT
Organism: Tachyglossus aculeatus aculeatus (Southeast Australian short-beaked echidna)
Family: Vasopressin/oxytocin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Tachyglossus aculeatus (species), Tachyglossus (genus), Tachyglossidae (family), Monotremata (order), Prototheria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.
Mechanism: NA
Cross BBB: NO
Target: NA
Target Unid: NA
IC50: Prostaglandin F metabolite(PGFM) release on administeration of 10 iu of oxytocin= 18.48±3.62 pg/ml ( PubMed ID: 10454085 )
EC50: NA
ED50: NA
kd: NA
Half life: 6.78 minutes; /406.8 seconds ( PubMed ID: 10454085 )

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004910_AF2.pdb

hor004910_ESM.pdb

Mass:	115308	Formula:	C43H67N11O13S2
Absent amino acids:	ADEFHKMRSTVW	Common amino acids:	C
pI:	5.81	Basic residues:	0
Polar residues:	5	Hydrophobic residues:	2
Hydrophobicity:	33.33	Boman Index:	102
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	86.67
Instability Index:	2708.89	Extinction Coefficient cystines:	1615
Absorbance 280nm:	201.88